Lithium borohydride: a reagent of choice for the selective reductive amination of cyclohexanones |
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| Authors: | Shawn Cabral Bernard Hulin |
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| Institution: | a Department of Cardiovascular and Metabolic Diseases, Groton, United States
b Department of Medicinal Chemistry-2 G3, Nagoya, United States |
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| Abstract: | Traditional reductive amination of substituted cyclohexanones are either selective toward the formation of cis-products or show low selectivity. Herein we report a selective procedure for the reductive amination of substituted cyclohexanones with primary amines using lithium borohydride that is selective toward formation of trans-products. |
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