Solubility of daidzin in different organic solvents and (ethyl alcohol + water) mixed solvents |
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| Institution: | 1. Graduate School of Pharmaceutical Sciences, Chiba University, Chuo-ku, Chiba, Chiba, Japan;2. Amine Pharma Research Institute, Innovation Plaza at Chiba University, Chuo-ku, Chiba, Chiba, Japan;3. RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan;4. Department of Rheumatology, Niigata Rheumatic Center, Shibata, Niigata, Japan;5. Niigata Prefectural Kamo Hospital, Kamo, Niigata, Japan;6. Faculty of Pharmacy, Chiba Institute of Science, Choshi, Chiba, Japan |
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| Abstract: | The solubility of daidzin in different organic solvents and (ethyl alcohol + water) mixed solvents was measured by high performance liquid chromatography (HPLC) analysis method from T = (283.2 to 323.2) K at atmosphere pressure. The results show that at higher temperature more daidzin dissolves, and moreover, the solubility increases with the ethyl alcohol mole fraction increase in the (ethyl alcohol + water) mixed solvents. The experimental solubility values were correlated by a simplified thermodynamic equation, λh equation and modified Apelblat equation. Based on the solubility of daidzin, the enthalpy and entropy of solution were also evaluated by van’t Hoff equation. The results illustrated that the dissolution process of daidzin is endothermic and entropy driven. |
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| Keywords: | Daidzin Solubility Correlation Organic solvent Ethyl alcohol plus water mixed solvents |
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