首页 | 本学科首页   官方微博 | 高级检索  
     


Role of Na(+)-Ca2+ exchange system in the pathogenesis of myocardial ischemia-reperfusion damage
Authors:Z P Li  C S Tang  J Y Su
Affiliation:Department of Pathophysiology, Beijing Medical University, PRC.
Abstract:Results from a systematic experiment on isolated perfused rat heart and isolated myocytes of adult rat showed that the mechanism of calcium influx during myocardial ischemia-reperfusion is due to the development of intracellular sodium overload during ischemic period; on reperfusion, the high intracellular Na+ content activated the reverse direction of Na(+)-Ca2+ exchange over myocardial sarcolemma (SL), thus a large quantity of extracellular Ca2+ fluxed over the SL to the intracellular space, forming a condition of intracellular Ca2+ overload, which leads to irreversible damage of the myocardium.
Keywords:
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号