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Use of enzymes in peptide synthesis |
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| Authors: | Irwin M. Chaiken Akira Komoriya Motonori Ohno Fred Widmer |
| Affiliation: | 1. Laboratory of Chemical Biology, National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases, USA 2. Laboratory of Chemoprevention, National Cancer Institute, National Institutes of Health, 20205, Bethesda, MD, USA |
| Abstract: | Recent experiments in several laboratories have emphasized the benefits of proteolytic enzymes as effective catalysts for the formation of peptide bonds for synthesis and semisynthesis. This review summarizes successful applications in both stepwise synthesis for small peptides and fragment condensation to produce large polypeptides and proteins. |
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