Multinuclear enantiopure titanium self‐assembly complexes—synthesis,characterization and application to organic synthesis |
| |
| Authors: | Bernd Schetter Christoph Stosiek Burkhard Ziemer Rainer Mahrwald |
| |
| Affiliation: | Humboldt‐Universit?t zu Berlin, Institut für Chemie, Brook‐Taylor Stra?e 2, 12489 Berlin, Germany |
| |
| Abstract: | ![]()
Hexa‐ and nonanuclear titanium complexes were obtained by self‐assembly of titanium(IV)‐tert‐butoxide and D ‐mandelic acid. Suitable single crystals of these complexes were characterized by X‐ray structure analysis. When used with these complexes, aldol adducts were isolated with a high degree of regioselectivity in direct aldol additions of aromatic and aliphatic aldehydes to functionalized unsymmetrical ketones. High syn‐diastereoselectivities were obtained in aldol additions of enolizable aldehydes with hydroxyacetone and methoxyacetone. Copyright © 2007 John Wiley & Sons, Ltd. |
| |
| Keywords: | chiral titanium complexes direct aldol addition carbonyl‐ene reaction |
|
|
