| X-RAY STUDIES ON THE STRUCTURE OF DES-PENTAPEPTIDE INSULIN AT 2.4 RESOLUTION——SOLUTION OF THE PHASE PROBLEM USING THE ANOMALOUS SCATTERING OF CADMIUM AND THE DERIVATION OF A MODEL STRUCTURE |
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| 引用本文： | D.STUART,戴金璧,楼美珍,游俊明,R.TODD,李家瑶,王家槐,梁栋材.X-RAY STUDIES ON THE STRUCTURE OF DES-PENTAPEPTIDE INSULIN AT 2.4 RESOLUTION——SOLUTION OF THE PHASE PROBLEM USING THE ANOMALOUS SCATTERING OF CADMIUM AND THE DERIVATION OF A MODEL STRUCTURE[J].中国科学B辑(英文版),1984(6). |
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| 作者姓名： | D.STUART 戴金璧 楼美珍 游俊明 R.TODD 李家瑶 王家槐 梁栋材 |
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| 作者单位： | Institute of Biophysics，Academia Sinica，Beijing Laboratory of Molecular Biophysics. Department of Zoology，South Parks Road，Oxford，OX 1 3PS，England.，Institute of Biophysics，Academia Sinica，Beijing，Institute of Biophysics，Academia Sinica，Beijing，Institute of Biophysics，Academia Sinica，Beijing，Institute of Biophysics，Academia Sinica，Beijing Laboratory of Molecular Biophysics. Department of Zoology，South Parks Road，Oxford，OX 1 3PS，England.，Institute of Biophysics，Academia Sinica，Beijing，Institute of Biophysics，Academia Sinica，Beijing，Institute of Biophysics，Academia Sinica，Beijing |
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| 摘 要： | The three dimensional structure of des-pentaptide insulin has been solved at a resolu-tion of 2.4A. The structure determination was achieved without the use of heavy atom de-rivatives, by using only the phase information obtained from the seattering (both real andimaginary) of X-rays by cadmium ions present in the native crystal. Using this phase in-formation, a map, with figure of merit 0.56, was produced which enabled an initial modelof the protein to be constructed. Because of the novelty of this approach to the solutionof the phase problem the procedures used are explained in some detail.
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