Tyrosine 92 of aristolochene synthase directs cyclisation of farnesyl pyrophosphate |
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Authors: | Calvert Melanie J Taylor Susan E Allemann Rudolf K |
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Affiliation: | School of Chemical Sciences, University of Birmingham, Edgbaston, Birmingham, UK B15 2TT. |
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Abstract: | ![]() A mutant of Aristolochene Synthase (AS), in which Tyr 92 was replaced by Val, produced the alicyclic beta-(E)-farnesene as the major product, indicating that cyclisation of FPP is controlled by Tyr 92 in AS. |
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