Formation and properties of HCO-10 vesicles |
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Authors: | C Sun M Ueno |
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Institution: | (1) Faculty of Pharmaceutical Sciences Toyama Medical and Pharmaceutical University 2630 Sugitani Toyama 930-01, Japan, JP |
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Abstract: | The characteristics of poly(oxyethylene) hydrogenated caster oil ether (HCO-10) vesicles were studied for the standpoints
of encapsulation efficiency, stability, solubilization and permeability or barrier efficiency. The vesicles of 5% HCO-10 had
6.24% of calcein-entrapment efficiency and 240 nm of mean diameter. The stability of HCO-10 vesicle suspensions was dependent
on their concentrations. In the vesicle suspensions of 10% HCO-10 or more, both the size of the vesicles and the fluidity
of the suspensions obviously varied with incubation time, indicating that a flocculation occurred; whereas, the vesicle suspension
of 5% HCO-10 was relatively stable. The solubilization process of HCO-10 vesicles by SDS was similar to that of EggPC liposomes.
The rate constants for permeation of Cl ion and calcein were 2.46×10-3 s-1 and 5.79×10-5 s-1, respectively, suggesting that HCO-10 vesicles possessed some barrier potential for Cl ion and calcein although they were
smaller than those of liposomes. Furthermore, the efflux of the solute such as calcein from HCO-10 vesicles was maximum at
37 °C, where the vesicle membrane was presumably destabilized by dehydration of EOs in HCO-10 molecules.
Received: 7 May 1996 Accepted: 3 September 1996 |
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Keywords: | HCO-10 vesicles encapsulation stability solubilization |
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