Synthesis and Biological Activity of Novel (E,E)-vic-dioximes |
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Authors: | Mükerrem Kurtoğlu M. Murat Dağdelen Sevil Toroğlu |
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Affiliation: | 1. Department of Chemistry, Faculty of Science and Arts, Kahramanmara? Süt?ü ?mam University, 46050-9, Kahramanmara?, Turkey 2. Department of Biology, Faculty of Science and Arts, Kahramanmara? Süt?ü ?mam University, 46050-9, Kahramanmara?, Turkey
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Abstract: | A novel vic-dioxime ligand containing the thiourea group, (4E,5E)-1,3-bis{4-[(4-methylphenylamino)methyl] phenyl}- 2-thiooxaimidazoline-4,5-dione dioxime, (4) mmdH2 has been prepared from N,N′-bis{4-[(4-methylphenylamino)methyl]phenyl}thiourea, (3) mft and cyanogen di-N-oxide. Mononuclear [M(mmdH)2], where M = NiII, CoII and CuII complexes of the (4) mmdH2 bidentate ligand have been obtained with a 1:2 metal:ligand ratio, as do most the vic-dioximes. The complexes are formed by coordination of N, N atoms of the ligand. The vic-dioxime ligand and its some transition metal complexes have been characterized by elemental analyses, molar conductance data, magnetic susceptibility, i.r., 1H-n.m.r and u.v.–vis. spectroscopy. Conductivity measurements have shown that mononuclear complexes are non-electrolytes. In addition, the ligands and metal complexes were screened for antibacterial and antifungal activities by agar well diffusion techniques using DMF as solvent. |
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