| Asymmetric Addition of Diethylzinc to Aldehydes Catalyzed by Chiral γ_Amino Alcohols |
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| 作者姓名： | Qian Yong XU Tong Xing WU Xin Fu PAN* |
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| 作者单位： | Qian Yong XU，Tong Xing WU，Xin Fu PAN* Department of Chemistry，National Laboratory of Applied Organic Chemistry，Lanzhou University，Lanzhou 730000 |
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| 基金项目： | Hong Kong Polytechnic University for the financial support. |
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| 摘 要： | Although the asymmetric additions of diethylzinc to aldehydes have been extensively studied in the presence of chiral catalyst, most of the chiral ligands tested are b-amino alcohols1. In this report, the synthesis of chiral gamino alcohols 1-4 from the reaction of (+)-camphor and (-)-menthone with 2-lithiomethyl-6-methyl-pyridine or 2-picolly- lithium2, which give a single diasteromer as determined by 1H NMR with high yields (Scheme 1)3, and their application in the enantioselective additio…
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