| 用荧光猝灭和荧光加强两种理论研究头孢类药物与白蛋白的作用 |
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| 引用本文： | 杨曼曼,席小莉,杨 频.用荧光猝灭和荧光加强两种理论研究头孢类药物与白蛋白的作用[J].中国化学,2006,24(5):642-648. |
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| 作者姓名： | 杨曼曼 席小莉 杨 频 |
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| 作者单位： | College of Chemistry and Chemical Engineering, Institute of Molecular Science, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China |
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| 基金项目： | Project supported by the National Natural Science Foundation of China （No. 30470408） and the Shanxi Provincial Natural Science Foundation |
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| 摘 要： | 应用荧光加强和荧光猝灭两种理论公式，对七种头孢类抗菌药物与人血清和牛血清白蛋白的作用作进行了对比研究，对药物与白蛋白的结合特点和通常的表征量：解离常数、猝灭常数、猝灭效率、能量转移效率、给体-受体作用距离等，进行了深入地分析。
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| 关 键 词： | 头孢菌素 人血清白蛋白 牛血清白蛋白 荧光增强 荧光淬火 |
| 收稿时间： | 2005-03-16 |
| 修稿时间： | 2005-03-162006-01-25 |
Study of the Interaction of Cephalosporin Class Medicine with Albumin by Fluorescence Enhancement and Fluorescence Quenching Theories |
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| YANG, Man-Man XI, Xiao-Li YANG, Pin.Study of the Interaction of Cephalosporin Class Medicine with Albumin by Fluorescence Enhancement and Fluorescence Quenching Theories[J].Chinese Journal of Chemistry,2006,24(5):642-648. |
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| Authors: | YANG Man-Man XI Xiao-Li YANG Pin |
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| Abstract: | The interaction of 7 kinds of cephalosporin-medicine with HSA and BSA was studied and compared using fluorescence enhancement and fluorescence quenching method, then deeply analyzed. The binding characteristics of medicine with albumin and usual characteristic constants such as dissociation constant, quenching constant, quenching efficiency, energy-transfer efficiency and the distance between donor and accepter were also deeply analyzed. |
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| Keywords: | fluorescence enhancement and quenching human serum albumin bovine serum albumin cephalosporin |
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