A new nucleophilic addition/ring-closure sequence. Enantioselective synthesis of 3-deoxy-8-oxatropanes |
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| Authors: | Nguyen Giang Perlmutter Patrick Rose Mark L Vounatsos Filisaty |
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| Affiliation: | School of Chemistry, Monash University, PO Box 23, Victoria 3800, Australia. patrick.perlmutter@sci.monash.edu.au |
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| Abstract: | ![]()
[reaction: see text] A study of new nucleophilic addition/ring-closure (NARC) sequences has resulted in the development of a stereoselective synthetic route to 3-deoxy-8-oxatropanes. The new sequences consisted of either a syn or anti aldol addition, employing an omega-alkenoyl sultam, followed by two-step bicyclic ring construction involving, consecutively, ring-closing metathesis and intramolecular oxymercuration. |
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