Synthesis of new potentially bioactive bicyclic 2-pyridones |
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| Authors: | Crozet Maxime D George Pascal Crozet Michel P Vanelle Patrice |
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| Institution: | Laboratory of Pharmaceutical Organic Chemistry, CNRS UMR 6517, University of the Méditerranée. (Aix - Marseille 2), Faculty of Pharmacy, 27 Bd Jean Moulin, 13385 Marseille Cedex 5, France. |
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| Abstract: | Three convenient methods of reduction of the nitro group of 5-nitroimidazoles and 5-nitrothiazole that bear a diethylmethylene malonate group in an ortho-like position with respect to the nitro group and cyclization of the resulting amino derivatives are reported. These reactions afforded the target bicyclic 2-pyridones in good to excellent yields. |
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