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Preparative Droplet Counter-Current Chromatography for the Separation of the New Nor-Seco-Triterpene and Pentacyclic Triterpenoids from Qualea Parviflora |
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| Authors: | A L M Nasser L P Mazzolin C A Hiruma-Lima L S Santos M N Eberlin A R Monteiro de Souza Brito W Vilegas |
| Institution: | 1. Instituto de Química de Araraquara, Universidade Estadual Paulista, C. Postal 355, 14801-970, Araraquara, SP, Brazil 2. Departamento de Farmacologia, Instituto de Biociências, Universidade Estadual Paulista, 18618-000, Botucatu, SP, Brazil 3. Instituto de Química, Universidade Estadual de Campinas, 13083-970, Campinas, SP, Brazil 4. Departamento de Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas, 13083-970, Campinas, SP, Brazil |
| Abstract: | The methanolic extract of the bark of the medicinal plant Qualea parviflora (Vochysiaceae) contains new nor-seco-triterpene and pentacyclic triterpenoids. They were separated in a preparative scale using droplet counter-current chromatography. The optimum solvent used was composed of a mixture of CHCl3/MeOH/H2O (43:37:20, v/v) in the descending mode and led to a successful separation of the new compound 28-nor-17, 22-seco-2α, 3β, 19, 22, 23-pentahydroxy-Δ12-oleanane, besides the known triterpenoids bellericagenin B, bellericaside B and arjunglucoside I . Identification was performed by ESI-MS, 1H NMR and 13C NMR analyses. |
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