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Comparison of Two Tricarbocyanine-Based Dyes for Fluorescence Optical Imaging |
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| Authors: | |
| Institution: | (1) Schering AG, Research Laboratories, Berlin, Germany;(2) Physikalisch-Technische Bundesanstalt, Berlin, Germany;(3) Schering AG, Clinical Development Diagnostics and Radiopharmaceuticals, Berlin, Germany;(4) Chirurgie und chirurgische Onkologie, Charité-Universitätsmedizin Berlin, Campus-Buch;(5) Schering AG, Optical Imaging & New Modalities Research, Müllerstrasse, 13342 Berlin, Germany |
| Abstract: | Optical technologies are evolving in many biomedical areas including the biomedical imaging disciplines. Regarding the absorption properties of physiological molecules in living tissue, the optical window ranging from 700 to 900 nm allows to use fluorescent dyes for novel diagnostic solutions. Here we investigate the potential of two different carbocyanine-based dyes fluorescent in the near infrared as contrast agents for in vivo imaging of subcutaneously grown tumours in laboratory animals. The primary aim was to modify the physicochemical properties of the previously synthesized dye SIDAG to investigate the effect on the in vivo imaging properties. |
| Keywords: | Optical imaging NIR-dyes contrast agents in vivo imaging tumour detection |
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