1‐(α‐Aminobenzyl)‐2‐naphthol as phosphine‐free ligand for Pd‐catalyzed Suzuki and one‐pot Wittig‐Suzuki reaction |
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| Authors: | A R Chaudhary A V Bedekar |
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| Institution: | Department of Chemistry, Faculty of Science, M. S. University of Baroda, , Vadodara, 390 002 Gujarat, India |
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| Abstract: | Air stable and easily accessible, 1‐(α‐aminobenzyl)‐2‐naphthols are used as efficient phosphine‐free ligands in palladium‐catalyzed Suzuki reaction for a variety of substrates under conventional heating as well as ultrasonic conditions. Multi‐brominated aromatic substrates were successfully converted to corresponding arylated moieties with good conversion and selectivity. A novel one‐pot two‐step cascade reaction strategy involving Wittig and Suzuki reactions is developed for efficient synthesis of 4‐styryl biphenyls (C6‐C2‐C6‐C6 unit). Copyright © 2012 John Wiley & Sons, Ltd. |
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| Keywords: | 1‐(α ‐aminobenzyl)‐2‐naphthols phosphine‐free Suzuki reaction homogeneous palladium catalysis one‐pot Wittig– Suzuki reaction |
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