Biological activity of selected boronic acids and their derivatives |
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| Authors: | Agnieszka Adamczyk‐Woźniak Olena Komarovska‐Porokhnyavets Bogusław Misterkiewicz Volodymyr P. Novikov Andrzej Sporzyński |
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| Affiliation: | 1. Physical Chemistry Department, Faculty of Chemistry, Warsaw University of Technology, , 00‐664 Warsaw, Poland;2. Department of Technology of Biological Active Substances, Pharmacy and Biotechnology, National University 'Lviv Polytechnic', , 79013 Lviv, Ukraine;3. Faculty of Materials, Science, Technology and Design, Technical University of Radom, , Radom, Poland |
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| Abstract: | A series of substituted phenylboronic acids and benzoxaboroles were evaluated for their antimicrobial activity. Antibacterial and antifungal action activity of several compounds was tested against Escherichia coli 67, Staphylococcus aureus 209‐p, Mycobacterium luteum VCM B‐868, Aspergillus niger VCM F‐1119 and Candida tenuis VCM Y‐70. Substituted phenylboronic acids have low biological activity against all the investigated species. Benzoxaboroles reveal higher biological activity in comparison with the corresponding acids. The highest activity was observed for small benzoxaborole molecules, and the unsubstituted benzoxaborole has only slightly lower biological activity as compared with the 5‐fluoro‐substituted one (AN2690). The compound possessing two oxaborole fragments has very high biological activity towards Mycobacterium luteum and both investigated fungi. Copyright © 2012 John Wiley & Sons, Ltd. |
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| Keywords: | boronic acids benzoxaboroles antibacterial activity antifungal activity |
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