| HKC细胞损伤对草酸钙晶体成核和聚集的促进作用 |
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| 引用本文： | 姚秀琼,邓穗平,欧阳健明.HKC细胞损伤对草酸钙晶体成核和聚集的促进作用[J].高等学校化学学报,2011,32(2):236-240. |
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| 作者姓名： | 姚秀琼 邓穗平 欧阳健明 |
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| 作者单位： | 暨南大学化学系, 生物矿化与结石病防治研究所, 广州 510632 |
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| 基金项目： | 国家自然科学基金(批准号:20971057)资助 |
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| 摘 要： | 采用H2O2对人肾小管上皮细胞(HKC)进行损伤. HKC损伤后，其活力降低，并表达骨桥蛋白(OPN). 损伤细胞促进草酸钙晶体的成核、聚集，并促进一水草酸钙(COM)晶体的形成，但对晶体生长的促进作用不明显. 本文结果提示，HKC细胞损伤后增加了肾结石形成的危险性.
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| 关 键 词： | 草酸钙 细胞调控 骨桥蛋白 生物矿化 HKC细胞 |
| 收稿时间： | 2010-05-10 |
Promotion on Nucleation and Aggregation of Calcium Oxalate Crystals by Injury of HKC Cell |
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| YAO Xiu-Qiong,DENG Sui-Ping,OUYANG Jian-Ming.Promotion on Nucleation and Aggregation of Calcium Oxalate Crystals by Injury of HKC Cell[J].Chemical Research In Chinese Universities,2011,32(2):236-240. |
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| Authors: | YAO Xiu-Qiong DENG Sui-Ping OUYANG Jian-Ming |
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| Institution: | Institute of Biomineralization and Lithiasis Research, Department of Chemistry, Jinan University, Guangzhou 510632, China |
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| Abstract: | Human renal tubular epithelial cells(HKC) were injured by H2O2.Cell damage caused the decreased viability of HKC,and the increased expression of osteopontin(OPN).With the injury time increased,cell viability continued to decline,and OPN expression also increased continuously.Compared to control cells,the number of crystals induced by the damaged cells increased significantly,and the aggregation level of the crystal also increased,but the effect on growth of calcium oxalate crystals was not significant.The c... |
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| Keywords: | Calcium oxalate Cell regulation Osteopontin Biomineralization HKC cell |
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