锌金属硫蛋白预防甲基汞对细胞膜损伤作用的实验研究

不同剂量的Ｚｎ可以诱导小鼠肝脏产生ＺｎＭＴ，随着实验组Ｚｎ剂量的增加，肝脏内ＺｎＭＴ的含量也相应增加，呈剂量效应增加（ｒ＝０．９９６）。ＺｎＭＴ具有保护膜构象、膜ＳＨ基、拮抗ＭｅＨｇ对膜流动性及膜通透性的损伤作用。本实验结果为ＺｎＭＴ预防甲基汞中毒提供了科学依据，同时显示了诱导ＺｎＭＴ的锌剂量要适当，过高则有毒性作用。

Study on Prevention of ZnMT against Membrane Damage Induced by MeHg

Different doses of Zn can induce different content of ZnMT in liver of mice. As the doses of Zn increased, the level of ZnMT increased and there was a dose-effect relationship between them (r=0.996). ZnMT can protect membrane configtion, SH and prevent MeHg from damaging the membrane fludity and permeability. The study provided the principle basis for preventing membrane damage of MeHg. The results also showed that the dose of Zn administered to mice should be appropriate, for over dose of Zn could bring damages to the drice.