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A practical synthesis of the ABC ring model of ecteinascidins |
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| Authors: | Saito N Tachi M Seki R Kamayachi H Kubo A |
| Affiliation: | Meiji Pharmaceutical University, Tokyo, Japan. |
| Abstract: | A practical synthesis of 1,2,3,4,5,6-hexahydro-1,5-imino-10-hydroxy-9-methoxy-3,8,11-trimethyl-3- benzazocin-4-one (3) as an ABC ring model compound of ecteinascidin 743 and safracins from 3-hydroxy-4-methoxy-5-methylbenzaldehyde (7) is described. The overall yield in 15 steps is 27%. |
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