Regio- and diastereoselective reductive coupling of vinylepoxides catalyzed by titanocene chloride |
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Authors: | Barrero Alejandro F Quílez del Moral José F Sánchez Elena M Arteaga Jesús F |
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Institution: | Department of Organic Chemistry, Institute of Biotechnology, University of Granada, Avda. Fuentenueva, 18071 Granada, Spain. afbarre@goliat.ugr.es |
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Abstract: | reaction: see text] The Ti(III)-catalyzed reaction of a series of vinylepoxides leads, with regio- and E-diastereoselectivity control, to good-to-excellent yields of the corresponding homocoupling products. This homocoupling reaction, which involves a new C-C bond-forming method, takes place via a S(N)2' process between an allyltitanium species and the starting vinylepoxide. The process can be used for the rapid and efficient formation of highly valuable intermediates for organic synthesis, as well as new interesting homologues of natural products. |
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