Flavonoids Isolated from Heat‐Processed Epimedium koreanum and Their Anti‐HIV‐1 Activities |
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| Authors: | Hong‐Mei Li Cheng Zhou Chin‐Ho Chen Rong‐Tao Li Kuo‐Hsiung Lee |
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| Institution: | 1. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, P.?R. China, (phone: +86‐871‐65920569;2. fax: +86‐871‐65920570);3. Surgical Science, Department of Surgery, University Medical Center, Durham, North Carolina, USA;4. Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, North Carolina 27599, USA, (phone: +1‐919‐9620066;5. fax: +1‐919‐9663893);6. Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung, Taiwan |
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| Abstract: | Systematic phytochemical investigation on heat‐processed Epimedium koreanum led to the isolation of 13 flavonoids, including five new prenyl‐flavonol glycosides, koreanosides A–E ( 1 – 5 , resp.). Their structures were elucidated on the basis of detailed analysis of the 1D‐ and 2D‐NMR spectroscopic data and chemical reactions. Apigenin ( 11 ) exhibited moderate anti‐HIV‐1 activity with an EC50 value of 12.8±3.27 μg/ml. |
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| Keywords: | Epimedium koreanum Prenyl‐flavonol glycosides Koreanosides A – E Anti‐HIV‐1 activities |
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