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First Stereoselective Synthesis of the Cytotoxic Polyketide (4R)‐1‐(3,5‐Dihydroxyphenyl)‐4‐hydroxypentan‐2‐one |
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| Authors: | Kothakonda Rajendra Prasad Sudina Purushotham Reddy Katragadda Suresh Babu Janaswamy Madhusudana Rao |
| Affiliation: | 1. Division of Natural Products Chemistry, Natural Products Laboratory, CSIR‐Indian Institute of Chemical Technology, Hyderabad?–?500?007, India, (phone: +91‐40‐27191881;2. fax: +91‐40‐27160512) |
| Abstract: | The first stereoselective synthesis of the cytotoxic polyketide (4R)‐1‐(3,5‐dihydroxyphenyl)‐4‐hydroxypentan‐2‐one ( 1 ) was achieved from readily available propylene oxide and 3,5‐dimethoxybenzyl alcohol. The synthesis involves Jacobsen's hydrolytic kinetic resolution (HKR) and Grignard reaction as key steps. |
| Keywords: | Exophiala pisciphila Polyketides Jacobsen's hydrolytic kinetic resolution (HKR) Grignard reaction |