Direct Arylation of 5‐Iodouracil and 5‐Iodouridine with Heteroarenes and Benzene via Photochemical Reaction |
| |
| Authors: | Qian Yang Tao Wei Yun He Yong Liang Zun‐Ting Zhang |
| |
| Affiliation: | 1. Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, and School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710062, P.?R. China (phone: +86‐29‐81530827);2. School of Sciences, Xi'an University of Technology, Xi'an 710054, P.?R. China;3. Department of Chemistry and Biochemistry, Florida International University, Miami, Florida 33199, USA |
| |
| Abstract: | ![]()
A method for the direct arylation of 5‐iodouracil and 5‐iodouridine was found to proceed in moderate yields. By irradiating mixtures of 5‐iodouracil or 5‐iodouridine and a series of five‐membered heterocycles such as 1H‐pyrrole, furan, 2‐methylfuran, 1‐methyl‐1H‐pyrrole, thiophene, as well as benzene in MeCN/H2O with a Hg lamp, 5‐aryluracils and 5‐aryluridines were synthesized. The reaction proceeded smoothly without the requirement of adding any transition metals or ligands. |
| |
| Keywords: | Arylation Uracil, 5‐iodo‐ Uridine, 5‐iodo‐ Photochemical reaction |
|
|
