Base‐Catalyzed Formation of Isoxazoles from Dialkyl Acetylenedicarboxylates and 2‐Nitroacetophenones |
| |
| Authors: | Sepehr Sadegh‐Samiei Issa Yavari Stavroula Skoulika |
| |
| Institution: | 1. Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran (phone: +98‐21‐82883465;2. fax: +98‐21‐82883455);3. Laboratory of Physical Chemistry, Department of Chemistry, The University of Ioannina, 45110 Ioannina, Greece |
| |
| Abstract: | The reaction of dialkyl acetylenedicarboxylates with 1‐aryl‐2‐nitroethanones in the presence of pyridine leads to dialkyl 5‐aryloyl‐isoxazole‐3,4‐dicarboxylates through a novel mechanism, which involves a 2+2] cycloaddition/ring opening/cyclization sequence. |
| |
| Keywords: | Isoxazole Cycloadditions Acetylenes Ethanones 1‐aryl‐2‐nitro‐ |
|
|
