One‐Pot Synthesis of 3‐Alkoxy‐2,3‐dihydro‐1H‐isoindol‐1‐ones by the Reactions of 2‐(Azidomethyl)benzoates with NaH |
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| Authors: | Kazuhiro Kobayashi Yuuki Chikazawa Kosuke Ezaki |
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| Institution: | Division of Applied Chemistry, Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4‐101 Koyama‐minami, Tottori 680‐8552, Japan, (phone/fax: +81‐857‐315263) |
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| Abstract: | A new and facile method for the general preparation of 3‐alkoxy‐2,3‐dihydro‐1H‐isoindol‐1‐ones has been developed. Thus, the reaction of 2‐(azidomethyl)benzoates with NaH affords, after workup with H2O, 3‐alkoxy‐2,3‐dihydro‐1H‐isoindol‐1‐ones 2 . 2‐Substituted 3‐alkoxy‐2,3‐dihydro‐1H‐isoindol‐1‐ones 4 can be obtained by adding alkyl halides prior to workup with H2O. |
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| Keywords: | 1H‐Isoindol‐1‐ones 3‐alkoxy‐2 3‐dihydro‐ Isoindolinones 3‐alkoxy‐ Benzoates 2‐(azidomethyl)‐ Benzyl anion Denitrogenation |
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