金属氮杂环卡宾配合物的抗肿瘤活性研究进展

自1978年顺铂成功地被开发成癌症临床治疗药物以来,金属配合物作为小分子抗癌药物的开发成为人们的研究热点。其中,氮杂环卡宾能与多种过渡金属中心形成稳定的共价键,这种特殊的稳定性使得金属氮杂环卡宾配合物具有被开发成药物的潜能。近年来,金属氮杂环卡宾配合物被发现具有良好的抗癌活性,激发了广大无机药物化学研究者的研究热情。综合笔者课题组在金属氮杂环卡宾抗肿瘤配合物方面的前期研究,本文将对银、金、铑和铂氮杂环卡宾配合物的抗肿瘤活性及作用机制进行综述,以期为新型金属氮杂环卡宾抗肿瘤化合物的设计合成提供参考。

Progress in Antitumor Activity of Metal N-Heterocyclic Carbene Complexes

Since the successful development of cisplatin as a clinical anticancer drug in 1978, the development of metal complexes as small molecule anticancer drugs has become a research hotspot. Because of the formation of stable covalent bonds between N-heterocyclic carbene and various transition metal centers, metal N-heterocyclic carbene complexes have the potential to be developed into drugs. Recently, metal N-heterocyclic carbene complexes have been found to have good anticancer activities, which have stimulated the research enthusiasm of the majority of inorganic medicinal chemistry researchers. Based on our previous study of metal N-heterocyclic carbene complexes as antitumor agents, in this review, the antitumor activities and mechanisms of silver, gold, rhodium and platinum N-heterocyclic carbene complexes are summarized. We hope this review could provide a reference for the design and synthesis of metal N-heterocyclic carbene complexes as antitumor agents.