Chemical double-mutant cycles: dissecting non-covalent interactions |
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| Authors: | Cockroft Scott L Hunter Christopher A |
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| Affiliation: | Centre for Chemical Biology, Department of Chemistry, Krebs Institute for Biomolecular Science, University of Sheffield, S3 7HF, UK. |
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| Abstract: | ![]()
Thermodynamic double-mutant cycles and triple-mutant boxes are widely employed for the experimental quantification of non-covalent interactions and cooperative effects in proteins. This review describes the application of these powerful methodologies to the study of non-covalent interactions in synthetic systems. |
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