Tupisteroide A–C,three new polyhydroxylated steroidal constituents from the roots of Tupistra chinensis |
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Authors: | Cheng‐Xiong Liu Zhi‐yong Guo Yan‐Hong Xue Hong‐Yan Zhang Hong‐Qi Zhang Kun Zou Nian‐Yu Huang |
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Institution: | Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, , Yichang, 443002 China |
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Abstract: | Three new steroidal compounds with polyhydroxy groups, tupisteroide A–C (1–3), were obtained from the roots of Tupistra chinensis, together with one known compound (4) that was isolated from this plant for the first time. The structures of tupisteroide A–C were determined on the basis of one‐ and two‐dimensional NMR spectroscopy, including 1H–1H Correlation Spectroscopy, Heteronuclear Multiple Bond Correlation, and Heteronuclear Single Quantum Coherence experiments. The isolated compounds were evaluated for their cytotoxic activities against A549, HepG2, and CaSki cancer cell lines in vitro. Among them, compounds 1, 2, and 4 did not show significant inhibitory activity, but compound 3 showed cytotoxicity against A549 cancer cell lines with IC50 values of 25.0 μM. Copyright © 2012 John Wiley & Sons, Ltd. |
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Keywords: | NMR 1H NMR 13C NMR 2‐D NMR steroidal saponin Tupistra chinensis |
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