The responses of preosteoblasts to collagen/hyaluronic acid polyelectrolyte multilayer coating on titanium |
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| Authors: | Xiaojun Li Qiaojie Luo Ying Huang Xiaodong Li Feng Zhang Shifang Zhao |
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| Affiliation: | Department of Oral and Maxillofacial Surgery, The Affiliated Stomatology Hospital, College of Medicine, Zhejiang University, Hangzhou, P. R. China |
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| Abstract: | The purpose of this study was to investigate the effect of Collagen/hyaluronic acid (Col/HA) polyelectrolyte multilayer (PEM) coating on the behaviors and function of pre‐osteoblastic cells. Col/HA PEM coating was fabricated on acid etched Ti disc via layer‐by‐layer technique. The formation and properties of Col/HA PEM coating were investigated using scanning electron microscope (SEM), contact angle and quartz crystal microbalance (QCM). Moreover, mouse preosteoblasts were used to evaluate the effect of Col/HA PEM coating on cell behaviors and function. The results of in vitro evaluations showed that the Col/HA PEM coating could accelerate the proliferation and differentiation of preosteoblasts cells. Copyright © 2011 John Wiley & Sons, Ltd. |
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| Keywords: | coating in vitro evaluation layer by layer technique surface modification |
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