NMR spectroscopic characterization of new 2,3‐dihydro‐1,3,4‐thiadiazole derivatives |
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| Authors: | M. Dora Carrión Luisa C. López‐Cara Mariem Chayah Duane Choquesillo‐Lazarte Miguel A. Gallo Antonio Espinosa Antonio Entrena M. Encarnación Camacho |
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| Affiliation: | 1. Departamento de Química Farmacéutica y Orgánica, Facultad de Farmacia, Universidad de Granada, , Granada, Spain;2. Laboratorio de Estudios Cristalográficos, IACT‐CSIC, , Granada, Spain |
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| Abstract: | The 1H and 13C NMR resonances of twenty‐seven 2,2‐dimethyl‐5‐(2‐nitrophenyl‐5‐substituted)‐2,3‐dihydro‐1,3,4‐thiadiazoles, and twenty‐seven 3‐acyl‐5‐(2‐amino‐5‐substituted)‐2,2‐dimethyl‐2,3‐dihydro‐1,3,4‐thiadiazoles were assigned completely using the concerted application of one‐dimensional and two‐dimensional experiments (DEPT, HMQC and HMBC). NOESY experiments, X‐ray crystallography and conformational analysis confirm the preferred conformation of these compounds. Copyright © 2012 John Wiley & Sons, Ltd. |
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| Keywords: | 1H and 13C 1D NMR, 1H and 13C 2D NMR (HMQC HMBC) NOESY 2,3‐dihydro‐1,3,4‐thiadiazole |
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