New method for the synthesis of metal complexes based on PtIV and substituted nicotinamides and isonicotinamides and investigation of their antimetastatic activity |
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| Authors: | Fedorov B S Fadeev M A Kozub G I Chekhlov A N Konovalova N P Sashenkova T E Berseneva E N Dobrokhotova O V Tatyanenko L V |
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| Institution: | 1.Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation
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| Abstract: | Complexes of platinum tetrachloride with substituted nicotinamides and isonicotinamides were synthesized by the reactions
of the corresponding amides with hexachloroplatinic acid. All these complexes are low-toxic. The strong antimetastatic activity
of these complexes against Lewis lung carcinoma and B16 melanoma experimental tumors was found in an enzyme system and was
then shown in experiments on animals. |
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