Abstract: | Redox reactions of disulfiram (DSF) were studied in aqueous solutions using the pulse-radiolysis technique. Reactions of DSF with one-electron oxidants Br2
- and N3, generated pulse radiolytically in aqueous solution at pH 7, yielded a transient (max = 480 nm) which exhibited the characteristics of a disulphide cation radical and decayed by second-order kinetics. Reactions of DSF with halogenated peroxyl radicals CCl3O2, CHCl2O2, CH2ClO2 and CBr3O2 led to the formation of an adduct absorbing at 580 nm. The reduction potential was estimated to be 1.24 ± 0.06 V vs. NHE. |