A route to annulated indoles via a palladium-catalyzed tandem alkylation/direct arylation reaction |
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| Authors: | Bressy Cyril Alberico Dino Lautens Mark |
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| Institution: | Davenport Laboratories, Chemistry Department, University of Toronto, Toronto, Ontario, Canada M5S 3H6. |
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| Abstract: | A norbornene-mediated palladium-catalyzed tandem alkylation/C-H functionalization sequence is described, in which an alkyl-aryl bond and a heteroaryl-aryl bond are formed in one pot. A variety of highly substituted six- and seven-membered ring annulated indoles were synthesized in good yields from bromoalkyl indoles and aryl iodides. |
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