Syntheses and antiulcer activities of 2-aminonorbornene derivatives. |
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| Authors: | H Yamazaki H Horikawa T Nishitani T Iwasaki K Nosaka H Tamaki |
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| Institution: | Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd., Osaka, Japan. |
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| Abstract: | 2,2,-Disubstituted norbornenes (1, 2), 2,2-Disubstituted norbornane (3), 2,2,3-trisubstituted norbornenes (4, 5), oxanorbornenes (6) and azanorbornenes (7) were synthesized by the Diels-Alder reaction using alpha, beta-dehydroamino acids as a key step, and their antiulcer activities were examined. The oxazolidine derivative (1h) exhibited the most potent activities against several ulcer-models in rat. |
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