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Optimized synthesis of [3-N]-labeled uridine phosphoramidites |
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| Authors: | Bharat Baral Pawan Kumar Brooke A Anderson Michael E stergaard Pawan K Sharma Patrick J Hrdlicka |
| Institution: | aDepartment of Chemistry, University of Idaho, Moscow, ID 83844-2343, USA;bDepartment of Chemistry, Kurukshetra University, Kurukshetra 136119, India |
| Abstract: | A short and high-yielding synthetic route to 3-15N]-labeled uridine phosphoramidite 1 (26% overall yield from uridine) has been developed. This will enable automated synthesis of isotopically labeled RNA strands and facilitate their use in structural studies. |
| Keywords: | Isotope labels NMR Nucleoside Phosphoramidite Ribonucleotides |
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