Effects of interpolation methods in spatial normalization of diffusion tensor imaging data on group comparison of fractional anisotropy |
| |
Authors: | Tzu-Cheng Chao Ming-Chung Chou Pinchen Yang Hsiao-Wen Chung Ming-Ting Wu |
| |
Affiliation: | 1. Department of Electrical Engineering, National Taiwan University, Taipei 106, Taiwan;2. Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan;3. Department of Radiology, Tri-Service General Hospital, Taipei 100, Taiwan;4. Department of Psychiatry, Kaohsiung Medical University, Kaohsiung 807, Taiwan;5. Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan;6. School of Medicine, National Yang-Ming University, Taipei 112, Taiwan |
| |
Abstract: | This study investigated the effects on the measurement of fractional anisotropy (FA) during interpolation of diffusion tensor images in spatial normalization, which is required for voxel-based statistics. Diffusion tensor imaging data were obtained from nine male patients with attention deficit/hyperactivity disorder and nine age-matched control subjects. Regions of interest were selected from the genu of corpus callosum (GCC) and the right anterior corona radiata (RACR), with FA values measured before and after spatial normalization using two interpolation algorithms: linear and rotationally linear. Computer simulations were performed to verify the experimental findings. Between-group difference in FA was observed in the GCC and RACR before spatial normalization (P<.00001). Interpolation reduced the measured FA values significantly (P<.00001 for both algorithms) but did not affect the group difference in the GCC. For the RACR, the between-group difference vanished (P=.968) after linear interpolation but was relatively unaffected by using rotationally linear interpolation (P=.00001). FA histogram analysis and computer simulations confirmed these findings. This work suggests that caution should be exercised in voxel-based group comparisons as spatial normalization may affect the FA value in nonnegligible degrees, particularly in brain areas with predominantly crossing fibers. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|