Elliptical magnetic resonance spectroscopic imaging with GRAPPA for imaging brain tumors at 3 T |
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| Authors: | Suchandrima Banerjee Esin Ozturk-Isik Sarah J. Nelson Sharmila Majumdar |
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| Affiliation: | 1. Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA;2. Joint Graduate Group in Bioengineering, University of California, San Francisco, and University of California, Berkeley, Berkeley CA 94720 and San Francisco, CA 94158, USA |
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| Abstract: | Magnetic Resonance Spectroscopic Imaging (MRSI) is a technique for imaging spatial variation of metabolites and has been very useful in characterizing biochemical changes associated with disease as well as response to therapy in malignant pathologies. This work presents a self-calibrated undersampling to accelerate 3D elliptical MRSI and an extrapolation-reconstruction algorithm based on the GRAPPA method. The accelerated MRSI technique was tested in three volunteers and five brain tumor patients. Acceleration allowed larger spatial coverage and consequently, less lipid contamination in spectra, compared to fully sampled acquisition within the same scantime. Metabolite concentrations measured from the accelerated acquisitions were in good agreement with measurements obtained from fully sampled MRSI scans. |
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| Keywords: | Elliptical MRI GRAPPA Brain tumors |
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