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One-step method for synthesis of 2,4-disubstituted quinazoline 3-oxides by reaction of a 2-aminoaryl ketone with a hydroxamic acid using Zn(OTf)2 as the catalyst |
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| Authors: | Sridhar Madabhushi Kishore Kumar Reddy Mallu Raveendra Jillella Srinivas Kurva Rajpal Singh |
| Institution: | 1. Fluoroorganics Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500607, India;2. Centre for Fire Explosives and Environmental Safety, DRDO, Timarpur, New Delhi 110054, India |
| Abstract: | A simple and efficient method for the preparation of 2,4-disubstituted quinazoline 3-oxides by reaction of a hydroxamic acid with 2-aminoaryl ketones using zinc(II) triflate as the catalyst is described. |
| Keywords: | 2-Aminoaryl ketone Hydroxamic acid Quinazoline 3-oxides Zinc(II) triflate Lewis acid catalysis |
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