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Stereoselective total synthesis of penaresidin A starting from d-galactal |
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| Authors: | BV Subba Reddy Ch KishoreA Srinivas Reddy |
| Institution: | Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India |
| Abstract: | A stereoselective total synthesis of penaresidin A has been accomplished involving Sharpless asymmetric epoxidation, regioselective ring-opening of epoxide, azetidine formation via SN2 reaction, Jung’s protocol, and Julia–Kocienski olefination. This approach has successfully demonstrated the synthetic utility of d-galactal in the construction of azetidine core of the natural product. |
| Keywords: | d-Galactal Asymmetric epoxidation Azetidine formation Jung&rsquo s protocol &ndash" target="_blank">Julia&ndash Kocienski olefination |
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