|
|||||
|
|
Total synthesis of Daphnodorin A |
|
| Authors: | Hu Yuan Kaijian Bi Wanlin Chang Rongcai Yue Bo Li Ji Ye Qingyan Sun Huizi Jin Lei Shan Weidong Zhang |
| Institution: | 1. Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China;2. School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China |
| Abstract: | A total synthesis of Daphnodorin A, a member of the Daphnodorins, was accomplished. Key features of the synthetic strategy include construction of 2-substituted-3-functionalized benzofuran via intramolecular Heck reaction and a mild Barton–McCombie deoxygenation process mediated by triethylborane. The total synthesis provided Daphnodorin A in 19.7% or 5.6% overall yield over 7 or 15 steps. |
| Keywords: | Daphnodorin A Total synthesis 2 3-Functionalized benzofuran Intramolecular Heck reaction Barton&ndash McCombie deoxygenation |
| 本文献已被 ScienceDirect 等数据库收录！ | |