A mild and efficient method for bromination of alcohols using α,α-dibromo-β-dicarbonyl compounds as halogen sources |
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| Authors: | Xiao-Meng Cui Yong-Hong Guan Na Li Hao Lv Lin-An Fu Kun Guo Xiaohui Fan |
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| Institution: | 1. School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China;2. Beijing National Laboratory for Molecular Sciences (BNLMS), Beijing 100190, China |
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| Abstract: | Exploration of α,α-dibromo-β-dicarbonyl compounds as novel bromine agents for the conversion of alcohols to alkyl bromides under neutral conditions has been achieved. This method can be used for acid-sensitive substrates and allows the bromination of various primary and secondary alcohols to proceed at room temperature within a very short period of time. |
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| Keywords: | Appel reaction α α-Dibromo-β-dicarbonyl compound Alcohol to bromide Triphenylphosphine |
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