Nano-copper catalyzed three-component reaction to construct 1,4-substituted 1,2,3-triazoles |
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| Authors: | Lina Huang Wei LiuJuncheng Wu Ying FuKehu Wang Congde Huo Zhengyin Du |
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| Institution: | Key Laboratory of Eco-Environment Related Polymer Materials of Ministry of Education, Key Laboratory of Polymer Materials of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, PR China |
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| Abstract: | Three-component reaction of alkyl halides, sodium azide with terminal alkynes can be catalyzed by nano-copper particles under ambient conditions. A series of 1,4-disubstituted-1,2,3-triazoles were obtained regioselectively by this one-pot strategy. Nano copper can be reused at least three times without significant deactivation. |
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| Keywords: | Copper nanoparticles Phenylacetylene Cycloaddition Click chemistry Multicomponent reaction |
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