Bistabercarpamines A and B,first vobasinyl-chippiine-type bisindole alkaloid from Tabernaemontana corymbosa |
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| Authors: | Ke Ma Jun-Song WangJun Luo Ming-Hua YangHe-Quan Yao Hong-Bin SunLing-Yi Kong |
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| Institution: | State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People’s Republic of China |
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| Abstract: | Two novel dimeric monoterpene indole alkaloids, bistabercarpamines A (1) and B (2) possessing unprecedented bis-vobasinyl-chippiine-type skeleton, were isolated from the leaves of Tabernaemontana corymbosa. The structures were elucidated on the basis of spectroscopic data, and the absolute configurations of these isolates were determined by CD excition chirality method. Bistabercarpamine A (1) exhibited moderate cell growth inhibitory activity against HepG-2 cells with IC50 of 38.14 ± 1.1 μM. |
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| Keywords: | Vobasinyl-chippiine-type bisindole alkaloid Bistabercarpamines A and B Cytotoxic activity Tabernaemontana corymbosa |
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