Ligand free open air copper(II) mediated aryl formamidation and amination of aryl halides |
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| Authors: | Rajesh Komati Branko S. Jursic |
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| Affiliation: | Department of Chemistry, University of New Orleans, New Orleans, LA 70148, United States; Stepharm LLC, PO Box 24220, New Orleans, LA 70119, United States |
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| Abstract: | ![]()
A simple synthetic procedure for direct formamidation and amination of aryl halides mediated by copper(II) salts was developed in open air, without an external ligand in formamide with potassium carbonate as a base. This approach is particularly efficient when electron active aryl halides are used as substrates. In these cases almost quantitative formamidation was observed. |
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| Keywords: | Copper coupling Anilines Aryl formamidation Aryl amination Aryl dimethylamination Formyl anilines |
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