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An efficient and highly stereoselective approach to trans-2,5-disubstituted-tetrahydrofuran and trans-2,6-disubstituted-tetrahydropyran derivatives |
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| Authors: | Indrek Veidenberg Lauri ToomPiret Villo Lauri Vares |
| Institution: | Institute of Technology, University of Tartu, Nooruse 1, Tartu 50411, Estonia |
| Abstract: | Bis-epoxides were converted into trans-2,5-disubstituted-tetrahydrofuran and trans-2,6-disubstituted-tetrahydropyran derivatives using a kinetic resolution followed by cyclization, in an efficient and highly enantio- and diastereoselective manner. |
| Keywords: | Tetrahydrofuran Tetrahydropyran Kinetic resolution Jacobsen&rsquo s catalyst Asymmetric synthesis |
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