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First enantioselective total synthesis of penicimarin B,aspergillumarins A and B |
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| Authors: | Jhillu Singh Yadav Anand Kumar MishraSoma Shekar Dachavaram S. Ganesh KumarSaibal Das |
| Affiliation: | Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, Andhra Pradesh, India |
| Abstract: | A convergent enantioselective synthesis of penicimarin B, aspergillumarin A and B has been reported using Brown’s allylation, DeBrabander–Bhattacharjee lactonization and Grubbs cross coupling metathesis. During this synthesis we have standardized the conditions for DeBrabande–Bhattacharjee lactonization to obtain excellent yield (>90%). |
| Keywords: | Penicimarin Aspergillumarin Brown&rsquo s allylation Grubbs catalyst Natural products |
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