Polyketides from the mangrove-derived endophytic fungus Acremonium strictum |
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| Authors: | Lena Hammerschmidt Abdessamad Debbab Tu Duong Ngoc Victor Wray Catalina Perèz Hemphil WenHan Lin Heike Broetz-Oesterhelt Matthias U Kassack Peter Proksch Amal H Aly |
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| Institution: | 1. Institut fuer Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine Universitaet, Universitaetsstrasse 1, Geb. 26.23., D-40225 Duesseldorf, Germany;2. Vietnamese Academy of Science and Technology, Institute of Chemistry, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi, Viet Nam;3. Helmholtz Centre for Infection Research, Inhoffenstraße 7, D-38124 Braunschweig, Germany;4. National Research Laboratories of Natural and Biomimetic Drugs, Peking University, Health Science Center, 100083 Beijing, People’s Republic of China;5. Institut fuer Pharmazeutische und Medizinische Chemie, Heinrich-Heine Universitaet, Universitaetsstrasse 1, Geb. 26.23., D-40225 Duesseldorf, Germany |
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| Abstract: | Five new polyketide derivatives, 6′-hydroxypestalotiopsone C (1), acropyrone (2), bicytosporone D (3), waol acid (4), and pestalotiopene C (5), together with seven known metabolites (6–12), were obtained from extracts of the endophytic fungus Acremonium strictum, isolated from the mangrove tree Rhizophora apiculata. The structures of the isolated compounds were elucidated on the basis of comprehensive NMR and MS analysis. Compounds 6, 7, and 9 showed moderate cytotoxic activity against human cisplatin-sensitive (IC50 values 27.1, 76.2, and 8.3 μM, respectively) and resistant A2780 cell lines (IC50 values 12.6, 30.1, and 19.0 μM, respectively), whereas only 9 exhibited antibacterial activity against Staphylococcus aureus (MIC value 14.3 μM). |
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| Keywords: | Acremonium strictum Cytotoxic activity Endophytic fungus Polyketides Rhizophora apiculata |
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