Highly efficient deprotection of phenolic tetrahydropyranyl and methoxymethyl ethers and sequel cyclization to indanones using Sn(IV)Cl4 catalyst |
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| Authors: | Naseem Ahmed Gulab Khushalrao PatheB. Venkata Babu |
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| Affiliation: | Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247 667, India |
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| Abstract: | ![]()
Sn(IV)Cl4 catalyst provided a rapid and efficient deprotection method for the phenolic THP and MOM ethers and sequel intramolecular Friedel–Crafts alkylation reaction of THP and MOM protected chalcone epoxides under mild conditions. The reaction took 2–3 min to give the products in excellent yield (90–98%) at 0 °C without affecting the other functional groups. |
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| Keywords: | Alcohol Phenol SnCl4 Detetrahydropyranylation Demethoxymethylation Friedel&ndash Crafts alkylation |
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