AsLn2, a luciferin-related modified tripeptide from the bioluminescent earthworm Fridericia heliota |
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| Authors: | Valentin N. Petushkov Maxim A. Dubinnyi Natalja S. Rodionova Kirill D. Nadezhdin Simone M. Marques Joaquim C.G. Esteves da Silva Osamu Shimomura Ilia V. Yampolsky |
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| Affiliation: | 1. Laboratory of Bioluminescent Biotechnologies, Institute of Fundamental Biology and Biotechnology, Siberian Federal University, pr. Svobodnyi, 79, Krasnoyarsk 660041, Russia;2. Laboratory of Photobiology, Institute of Biophysics, Siberian Branch of the Russian Academy of Sciences, Akademgorodok, Krasnoyarsk 660036, Russia;3. Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, Moscow 117997, Russia;4. Chemistry Research Center of the University of Porto (CIQ-UP), Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Campo Alegre St. 687, Porto 4169-007, Portugal |
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| Abstract: | AsLn2, an unusual modified peptide, was isolated from the bioluminescent earthworm Fridericia heliota (Enchytraeidae). Its structure, elucidated by NMR and mass spectrometry, includes residues of tyrosine, CompX (a novel tyrosine modification product, reported in the accompanying paper), and N(omega)-acylated lysine. Chromatography, UV, and 1H NMR data imply a close structural similarity of AsLn2 with F. heliota luciferin. AsLn2 appears to be an intermediate or by-product in F. heliota luciferin biosynthesis. |
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| Keywords: | Bioluminescence Fridericia heliota Luciferin Modified peptide |
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